AffiAB® Anti-FOXA1 Antibody [JF10-02]

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CAT# AFG-HB-1500
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-FOXA1 Antibody [JF10-02]

Forkhead box protein A1 (FOXA1) , also known as hepatocyte nuclear factor 3-alpha (HNF-3A) , is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. Mutations in this gene have been recurrently seen in instances of prostate cancer. Expression of FOXA1 correlates with two EMT markers, namely Twist1 and E-cadherin in breast cancer.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P55317 Human; SwissProt: P35582 Mouse; SwissProt: P23512 Rat

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

JF10-02

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

WB, IF-Cell, IF-Tissue, IHC-P

Predicted species reactivity

N/A

Immunogen

Recombinant protein within Human FOXA1 aa 320-472 / 472.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200

Molecular Weight

Predicted band size: 49 kDa

Subcellular location

Nucleus.

Positive control

SK-Br-3 cell lysate, MCF-7 cell lysate, MCF-7, rat prostate tissue, human breast tissue, mouse colon tissue, human breast carcinoma tissue.