AffiAB® Anti-FGF21 Antibody [JA10-97]

Fibroblast growth factor-1 (FGF-1) , also designated acidic FGF, and fibroblast growth factor-2 (FGF-2) , also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithe-lial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi) , FGF-5, FGF-6, FGF-7 (KGF) , FGF-8 (AIGF) , FGF-9 (GAF) and FGF-10-FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1) , Bek (FGFR-L) , TKF and FGFR-3.