![AffiAB® Anti-FBP1 Antibody [JE48-70]](/web/image/product.product/74256/image_1024/%5BAFG-HB-1433%5D%20AffiAB%C2%AE%20Anti-FBP1%20Antibody%20%5BJE48-70%5D%20?unique=a48b62f)
AffiAB® Anti-FBP1 Antibody [JE48-70]
Catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P09467 Human; SwissProt: Q9QXD6 Mouse; SwissProt: P19112 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JE48-70
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human FBP1 aa 244-338 / 338.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/ml.
Purity
Protein A affinity purified.
Signal pathway
AMPK signaling pathway
Recommended dilutions
WB:1:500-1:1000; IF-Cell:1:50-1:200; IHC-P:1:50-1:200
Molecular Weight
Predicted band size: 37 kDa
Subcellular location
Cytoplasm. Nucleus. Extracellular exosome.
Positive control
MCF-7 cell lysate, human liver tissue lysate, PANC-1, rat urinary bladder tissue, human kidney tissue, human small intestine tissue, human pancreas tissue, mouse liver tissue.