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AffiAB® Anti-Fas (CD95) Antibody [JJ0942]
The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT) , cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6) , is a protein that in humans is encoded by the FAS gene.Fas was first identified using a monoclonal antibody generated by immunizing mice with the FS-7 cell line. Thus, the name Fas is derived from FS-7-associated surface antigen.The Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) if it binds its ligand, Fas ligand (FasL) . It is one of two apoptosis pathways, the other being the mitochondrial pathway. [8]
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P25445 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JJ0942
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human Fas aa 130-335 / 335.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
p53 signaling pathway, Immunology & Inflammation, Alzheimer disease, Apotosis, MAPK signaling pathway
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:50-1:100
Molecular Weight
Predicted band size: 37 kDa
Subcellular location
Cell membrane, Secreted.
Positive control
Hela cell lysate, A431 cell lysate, HepG2, Hela, human tonsil tissue, human kidney tissue, Raji.