AffiAB® Anti-ESRRB Antibody
Steroid hormone receptors are found on the plasma membrane, in the cytosol and also in the nucleus of target cells. They are generally intracellular receptors and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days. Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) . DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: O95718 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human ESRRB aa 168-212.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000; IHC-P: 1:200; IF-Cell: 1:100-1:200
Molecular Weight
Predicted band size: 48 kDa
Subcellular location
Nucleus, Cytoplasm, Chromosome.
Positive control
F9 cell lysate, A549 cell lysate, human brain tissue, rat brain tissue, hela.