AffiAB® Anti-DNA2 Antibody
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: P51530 Human; SwissProt: Q6ZQJ5 Mouse; SwissProt: D3ZG52 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human DNA2 aa 960-1000.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000
; IHC-P: 1:50-1:200
; FC: 1:50-1:100
Molecular Weight
Predicted band size: 120 kDa.
Subcellular location
Mitochondrion, Nucleus.
Positive control
Human stomach tissue lysates, rat large intestine tissue, human liver tissue, human kidney tissue, mouse kidney tissue, HL-60.