![AffiAB® Anti-Hu CD23 PerCP-Cy5.5 [EBVCS-5]](/web/image/product.product/83830/image_1024/%5BAFG-EXB-2331%5D%20AffiAB%C2%AE%20Anti-Hu%20CD23%20PerCP-Cy5.5%20%5BEBVCS-5%5D?unique=d31c23b)
Overview
CD23 (Fc epsilon RII), the low affinity IgE receptor, is a 45 kDa type II membrane glycoprotein expressed more or less on eosinophils, follicular dendritic cells, Langerhans cells, mature B cells (mainly upon activation), EBV-transformed lymphoblasts, monocytes, and subpopulation of platelets. A soluble form of 37 kDa and other its fragments were also described. CD23 mediates IgE-dependent cytotoxicity by eosinophils and macrophages, and downregulates IgE secretion in response to high levels of IgE, involving release of pro-inflammatory cytokines.
Specificity:
The mouse monoclonal antibody EBVCS-5 recognizes an extracellular epitope located in the stalk region of human low affinity IgE receptor (CD23) between the 37 and 25 kDa cleavage sites.
Antigen
CD23
Clone
EBVCS-5
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
EBV-transformed human cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PerCP-Cy5.5
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide