![AffiAB® Anti-Hu CD107a PerCP-Cy5.5 [H4A3]](/web/image/product.product/83827/image_1024/%5BAFG-EXB-2328%5D%20AffiAB%C2%AE%20Anti-Hu%20CD107a%20PerCP-Cy5.5%20%5BH4A3%5D?unique=d31c23b)
Overview
CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.
Specificity:
The mouse monoclonal antibody H4A3 recognizes an extracellular/luminal epitope of CD107a, an approximately 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
Antigen
CD107a
Clone
H4A3
Species Reactivity
Human, Non-human primates, Mouse
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
Human PBMC
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PerCP-Cy5.5
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide