![AffiAB® Anti-Hu CD34 PerCP-Cy5.5 [581]](/web/image/product.product/83826/image_1024/%5BAFG-EXB-2327%5D%20AffiAB%C2%AE%20Anti-Hu%20CD34%20PerCP-Cy5.5%20%5B581%5D?unique=d31c23b)
Overview
CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.
Specificity:
The mouse monoclonal antibody 581 reacts with an extracellular epitope of CD34, a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. The antibody recognizes the class III CD34 epitope resistant to neuraminidase, chymopapain and glycoprotease.
Antigen
CD34
Clone
581
Species Reactivity
Non-human primates, Human
Negative Species
Sheep
Isotype
Mouse IgG1 kappa
Immunogen
N/A
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PerCP-Cy5.5
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide