![AffiAB® Anti-Hu CD86 PE-Cy5 [BU63]](/web/image/product.product/83760/image_1024/%5BAFG-EXB-2261%5D%20AffiAB%C2%AE%20Anti-Hu%20CD86%20PE-Cy5%20%5BBU63%5D?unique=d31c23b)
Overview
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152) . The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Specificity:
The mouse monoclonal antibody BU63 reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Antigen
CD86
Clone
BU63
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
B-lymphoblastoid cell line ARH 77
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy5
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide