![AffiAB® Anti-Hu CD41 PE-Cy5 [MEM-06]](/web/image/product.product/83752/image_1024/%5BAFG-EXB-2253%5D%20AffiAB%C2%AE%20Anti-Hu%20CD41%20PE-Cy5%20%5BMEM-06%5D?unique=d31c23b)
Overview
CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Specificity:
The antibody MEM-06 reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa) . CD41 is mainly expressed on platelets and megakaryocytes.
Antigen
CD41
Clone
MEM-06
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Leukocytes of patient suffering from LGL-type leukaemia.
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy5
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide