![AffiAB® Anti-Hu CD56 PE-Cy5 [MEM-188]](/web/image/product.product/83746/image_1024/%5BAFG-EXB-2247%5D%20AffiAB%C2%AE%20Anti-Hu%20CD56%20PE-Cy5%20%5BMEM-188%5D?unique=d31c23b)
Overview
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.
Specificity:
The antibody MEM-188 reacts with an extracellular epitope on a 180 kDa isoform of CD56 (NCAM) expressed in leukocytes. It has been suggested that the antibody MEM-188 could react with rhesus monkey lymphocytes. Reactivity with other NCAM isoforms has not been tested.
Antigen
CD56
Clone
MEM-188
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG2a
Immunogen
KG-1 human acute myelogenous leukemia cell line
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy5
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide