![AffiAB® Anti-Hu CD55 PE-Cy5 [MEM-118]](/web/image/product.product/83745/image_1024/%5BAFG-EXB-2246%5D%20AffiAB%C2%AE%20Anti-Hu%20CD55%20PE-Cy5%20%5BMEM-118%5D?unique=d31c23b)
Overview
CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can still regulate complement when bound to CD97. In tumours, besides protection agains complement, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis.
Specificity:
The antibody MEM-118 recognizes an epitope in SCR4 domain of CD55 (Decay accelerating factor, DAF), a 60-70 kDa glycosylphosphatidylinositol (GPI) -anchored single chain extracellular glycoprotein. CD55 is widely expressed on hematopoietic and on many non-hematopoietic cells; it is weakly present on NK cells.
Antigen
CD55
Clone
MEM-118
Species Reactivity
Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgM
Immunogen
HPB-ALL human T cell line
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy5
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide