![AffiAB® Anti-Hu CD152 PE-Cy7 [BNI3]](/web/image/product.product/83732/image_1024/%5BAFG-EXB-2233%5D%20AffiAB%C2%AE%20Anti-Hu%20CD152%20PE-Cy7%20%5BBNI3%5D?unique=d31c23b)
Overview
CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.
Specificity:
The mouse monoclonal antibody BNI3 recognizes an extracellular domain of human CD152 / CTLA4, an approximately 45 kDa type I transmembrane protein serving as a negative regulator of T cell responses.
Antigen
CD152
Clone
BNI3
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2a
Immunogen
Human CD152-IgG heavy chain fusion protein
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy7
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide