![AffiAB® Anti-Hu CD144 PE-Cy7 [55-7H1]](/web/image/product.product/83727/image_1024/%5BAFG-EXB-2228%5D%20AffiAB%C2%AE%20Anti-Hu%20CD144%20PE-Cy7%20%5B55-7H1%5D?unique=d31c23b)
Overview
CD144 / VE-cadherin (cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (delta1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability.
Specificity:
The mouse monoclonal antibody 55-7H1 recognizes a calcium-independent extracellular epitope on CD144 (VE-cadherin, cadherin 5), an adhesion molecule expressed on endothelial cells.
Antigen
CD144
Clone
55-7H1
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
Human endothelial cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy7
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide