![AffiAB® Anti-Hu CD271 PE-Cy7 [NGFR5]](/web/image/product.product/83703/image_1024/%5BAFG-EXB-2204%5D%20AffiAB%C2%AE%20Anti-Hu%20CD271%20PE-Cy7%20%5BNGFR5%5D?unique=d31c23b)
Overview
CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
Specificity:
The mouse monoclonal antibody NGFR5 (originally C34C) recognizes an epitope within ammino acids 1 - 160 of CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily.
Antigen
CD271
Clone
NGFR5
Species Reactivity
Human, Rabbit, Cat, Non-human primates, Ferret
Negative Species
Mouse, Rat
Isotype
Mouse IgG1
Immunogen
Purified CD271 protein isolated from human melanoma cell line A875
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy7
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide