![AffiAB® Anti-Hu CD203c PE-Cy7 [NP4D6]](/web/image/product.product/83696/image_1024/%5BAFG-EXB-2197%5D%20AffiAB%C2%AE%20Anti-Hu%20CD203c%20PE-Cy7%20%5BNP4D6%5D?unique=d31c23b)
Overview
CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.
Specificity:
The mouse monoclonal antibody NP4D6 reacts with an extracellular epitope of CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
Antigen
CD203c
Clone
NP4D6
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
HEK-293 cells transfected with human CD203c
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy7
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide