![AffiAB® Anti-Hu CD11c PE-Cy7 [BU15]](/web/image/product.product/83688/image_1024/%5BAFG-EXB-2189%5D%20AffiAB%C2%AE%20Anti-Hu%20CD11c%20PE-Cy7%20%5BBU15%5D?unique=d31c23b)
Overview
CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.
Specificity:
The antibody BU15 reacts with an extracellular epitope of CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.
Antigen
CD11c
Clone
BU15
Species Reactivity
Human, Monkey
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Dendritic cells of synovial fluid
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy7
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide