![AffiAB® Anti-Hu CD231 PE-Cy7 [B2D]](/web/image/product.product/83662/image_1024/%5BAFG-EXB-2163%5D%20AffiAB%C2%AE%20Anti-Hu%20CD231%20PE-Cy7%20%5BB2D%5D?unique=d31c23b)
Overview
CD231 (TALLA-1, T-ALL-asociated antigen 1), also known as tetraspanin 7, is a 150 kDa (under reducing conditions 32-45 kDa) transmembrane glycoprotein of tetraspanin family, expressed in T-type acute lymphoblastic leukemia, neuroblastoma, and neuronal tissue. Mutations of CD231 gene are associated with X-linked mental retardation, Huntington´s chorea, and myotonic dystrophy. CD231 interacts with integrins and may have a role in the control of neurite outgrowth. Antibodies to CD231 are important for detection of T-ALL and are potential targets of its treatment.
Specificity:
The mouse monoclonal antibody B2D recognizes an extracellular epitope of CD231 (TALLA-1, tetraspanin 7), a transmembrane glycoprotein expressed in neuronal tissue and T-ALL.
Antigen
CD231
Clone
B2D
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Human T-ALL cell line THP-6
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy7
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide