![AffiAB® Anti-Hu CD279 PE-Cy7 [EH12.2H7]](/web/image/product.product/83659/image_1024/%5BAFG-EXB-2160%5D%20AffiAB%C2%AE%20Anti-Hu%20CD279%20PE-Cy7%20%5BEH12.2H7%5D?unique=d31c23b)
Overview
CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its ligands CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.
Specificity:
The mouse monoclonal antibody EH12.2H7 recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes.
Antigen
CD279
Clone
EH12.2H7
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
recombinant human CD279
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-Cy7
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide