![AffiAB® Anti-Hu CD13 PE-DyLight 594 [WM15]](/web/image/product.product/83644/image_1024/%5BAFG-EXB-2145%5D%20AffiAB%C2%AE%20Anti-Hu%20CD13%20PE-DyLight%20594%20%5BWM15%5D?unique=d31c23b)
Overview
CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.
Specificity:
The antibody WM15 recognises an extracellular epitope of human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
Antigen
CD13
Clone
WM15
Species Reactivity
Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Human AML cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-DyLight® 594
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide