![AffiAB® Anti-Hu CD45RA PE-DyLight 594 [MEM-56]](/web/image/product.product/83635/image_1024/%5BAFG-EXB-2136%5D%20AffiAB%C2%AE%20Anti-Hu%20CD45RA%20PE-DyLight%20594%20%5BMEM-56%5D?unique=d31c23b)
Overview
CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naïve T cells and normal plasma cells.
Specificity:
The antibody MEM-56 reacts with an extracellular epitope of CD45RA, a 205-220 kDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform) . CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.
Antigen
CD45RA
Clone
MEM-56
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2b
Immunogen
Human thymocytes and T lymphocytes.
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE-DyLight® 594
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide