![AffiAB® Anti-Hu CD146 PerCP [P1H12]](/web/image/product.product/83561/image_1024/%5BAFG-EXB-2062%5D%20AffiAB%C2%AE%20Anti-Hu%20CD146%20PerCP%20%5BP1H12%5D?unique=d31c23b)
Overview
CD146, also known as MCAM (melanoma cell adhesion molecule) or MUC18, is a heavily glycosylated transmembrane glycoprotein with more than 50% of the mass from carbohydrates. It is expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, activated T cells and activated keratinocytes, and on some cancer cells, especially melanoma. The presence of CD146 on circulating blood cells has been confined to the activated T cells rather than circulating endothelial cells. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration.
Specificity:
The mouse monoclonal antibody P1H12 recognizes an extracellular epitope of CD146, a 118 kDa transmembrane glycoprotein expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, melanoma cells, activated T cells and activated keratinocytes.
Antigen
CD146
Clone
P1H12
Species Reactivity
Rabbit, Dog, Mouse, Human
Negative Species
Rat
Isotype
Mouse IgG1
Immunogen
cultured human umbilical cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PerCP
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide