![AffiAB® Anti-Hu CD1d Alexa Fluor 647 [51.1]](/web/image/product.product/83384/image_1024/%5BAFG-EXB-1885%5D%20AffiAB%C2%AE%20Anti-Hu%20CD1d%20Alexa%20Fluor%20647%20%5B51.1%5D?unique=d31c23b)
Overview
CD1d belongs to CD1 family of transmembrane glycoproteins, associated with beta2 microglobulin, similarly to MHC I molecules. Unlike other CD1 family members, however, CD1d can be also expressed in a non-glycosylated form, which is not associated with beta2 microglobulin. Hence it is not certain how much CD1d plays a role in the presentation of microbial lipid antigens during infection. On the other hand, it is expressed on various antigen presenting cell types. Besides it, CD1d+ thymocytes are involved in the positive selection of sublineage of NKT cells.
Specificity:
The mouse monoclonal antibody 51.1 recognizes an extracellular epitope of CD1d, a 38 kDa transmembrane glycoprotein expressed mainly on cortical thymocytes, marginal zone B cells and other antigen presenting cells, but also i e.g. hepatitis C virus-infected livers.
Antigen
CD1d
Clone
51.1
Species Reactivity
Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgG2b kappa
Immunogen
human CD1d
Application
IHC (F), WB, FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 647
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide