![AffiAB® Anti-Hu CD243 Alexa Fluor 647 [UIC2]](/web/image/product.product/83379/image_1024/%5BAFG-EXB-1880%5D%20AffiAB%C2%AE%20Anti-Hu%20CD243%20Alexa%20Fluor%20647%20%5BUIC2%5D?unique=d31c23b)
Overview
CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC) -containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes) .
Specificity:
The mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells. This antibody preferentially recognizes CD243 in the process of transporting substrate.
Antigen
CD243
Clone
UIC2
Species Reactivity
Human
Negative Species
Mouse, Rat
Isotype
Mouse IgG2a kappa
Immunogen
NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 647
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide