![AffiAB® Anti-Hu CD150 Alexa Fluor 647 [SLAM.4]](/web/image/product.product/83367/image_1024/%5BAFG-EXB-1868%5D%20AffiAB%C2%AE%20Anti-Hu%20CD150%20Alexa%20Fluor%20647%20%5BSLAM.4%5D?unique=d31c23b)
Overview
CD150, also known as SLAM (signaling lymphocyte activation molecule) is a 70-95 kDa single chain transmembrane phosphoglycoprotein of the CD2 family. Its extracellular part contains eight potential N-glycosylation sites, and the intracellular tail contains three unique tyrosine-based motifs. These binding sites can be recognized by SH2-binding phosphatases and the adaptor proteins, such as SAP/SH2D1A or EAT-2. The SLAM family receptors are involved in leucocyte activation and contribute to the effective germinal center formation, generation of high-affinity antibody-secreting plasma cells, and memory T and B cells, thereby facilitating long-term immune response. CD150 expression is upregulated after cell activation.
Specificity:
The mouse monoclonal antibody SLAM.4 recognizes an extracellular epitope of CD150, a cell surface molecule expressed on lymphocytes and involved in their activation.
Antigen
CD150
Clone
SLAM.4
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Human CD150-transfected 300.19 cells
Application
FC (QC tested), ICC
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 647
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide