![AffiAB® Anti-Hu CD273 Alexa Fluor 647 [24F.10C12]](/web/image/product.product/83337/image_1024/%5BAFG-EXB-1838%5D%20AffiAB%C2%AE%20Anti-Hu%20CD273%20Alexa%20Fluor%20647%20%5B24F.10C12%5D?unique=d31c23b)
Overview
CD273 / PD-L2 (programmed death ligand-1), also known as B7-DC, is a member of the B7 family of regulatory proteins. It costimulates the proliferation of T cells, and mediates IFN gamma production. Ligation of CD273 on dendritic cells enhances dendritic cell activation and T cell responses. When interacting with CD279, it can act as a coinhibitor of the T cell function. CD273 expression is a useful marker to distinguish primary mediastinal B cell lymphoma from other diffuse large B cell lymphomas.
Specificity:
The mouse monoclonal antibody 24F.10C12 recognizes an extracellular epitope of CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL) .
Antigen
CD273
Clone
24F.10C12
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2a kappa
Immunogen
human CD273 cDNA
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 647
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide