![AffiAB® Anti-Hu CD193 Alexa Fluor 647 [5E8]](/web/image/product.product/83334/image_1024/%5BAFG-EXB-1835%5D%20AffiAB%C2%AE%20Anti-Hu%20CD193%20Alexa%20Fluor%20647%20%5B5E8%5D?unique=d31c23b)
Overview
CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES) . It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
Specificity:
The mouse monoclonal antibody 5E8 recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
Antigen
CD193
Clone
5E8
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2b kappa
Immunogen
human CD193 transfectants
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 647
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide