![AffiAB® Anti-HDAC6 Alexa Fluor 488 [236]](/web/image/product.product/83327/image_1024/%5BAFG-EXB-1828%5D%20AffiAB%C2%AE%20Anti-HDAC6%20Alexa%20Fluor%20488%20%5B236%5D?unique=24195c2)
Overview
Histone deacetylase 6 (HDAC6), like other histone deacetylases, affects gene expression by regulation of chromatin remodeling. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. Besides histones, HDAC6 deacetylates also other substrates including alpha tubulin and HSP90 alpha, and is involved in protein trafficking and degradation, as well as in affecting of cell shape and migration. Deregulation of HDAC6 expression and activity is associated with many diseases.
Specificity:
The mouse monoclonal antibody 236 recognizes D1 domain of human histone deacetylase 6 (HDAC6; intracellular antigen), amino acids 71-91.
Antigen
HDAC6
Clone
236
Species Reactivity
Human
Negative Species
Mouse, Danio
Isotype
Mouse IgG2b kappa
Immunogen
human HDAC6
Application
WB, ICC, FC (QC tested)
Regulatory status
RUO
Concentration
0.1 mg/ml
Format
Alexa Fluor® 488
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide