![AffiAB® Anti-Hu CD161 Alexa Fluor 488 [HP-3G10]](/web/image/product.product/83319/image_1024/%5BAFG-EXB-1820%5D%20AffiAB%C2%AE%20Anti-Hu%20CD161%20Alexa%20Fluor%20488%20%5BHP-3G10%5D?unique=d31c23b)
Overview
CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.
Specificity:
The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.
Antigen
CD161
Clone
HP-3G10
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
human NK cells
Application
FC (QC tested), WB
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 488
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide