![AffiAB® Anti-Hu CD300a Alexa Fluor 488 [MEM-260]](/web/image/product.product/83297/image_1024/%5BAFG-EXB-1798%5D%20AffiAB%C2%AE%20Anti-Hu%20CD300a%20Alexa%20Fluor%20488%20%5BMEM-260%5D?unique=d31c23b)
Overview
CD300a (CMRF-35H, IRp60) is a non-MHC-specific inhibitory receptor of immunoglobulin superfamily, which contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that associate with SH2-containing phosphatases SHP-1 and SHP-2. CD300a is expressed on many cell types including T cells, NK cells, neutrophils, eosinophils or mast cells. Its triggering inhibits activating signals such as those of IL5, GM-CSF or eotaxin, as well as supresses mast cell degranulation or NK cell cytotoxic activity.
Specificity:
The antibody MEM-260 reacts with an extracellular epitope of CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells.
Antigen
CD300a
Clone
MEM-260
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
HPB human acute lymphoid leukemia cell line
Application
FC (QC tested), WB
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 488
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide