![AffiAB® Anti-Bov CD18 Alexa Fluor 488 [IVA35]](/web/image/product.product/83287/image_1024/%5BAFG-EXB-1788%5D%20AffiAB%C2%AE%20Anti-Bov%20CD18%20Alexa%20Fluor%20488%20%5BIVA35%5D?unique=d31c23b)
Overview
CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18) . In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
Specificity:
The antibody IVA35 reacts with an extracellular epitope of CD18 antigen (bovine), a 90-95 kDa type I transmembrane protein (integrin) expressed on all leukocytes.
Antigen
CD18
Clone
IVA35
Species Reactivity
Cow, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Bovine leukocytes.
Application
ICC, FC (QC tested)
Regulatory status
RUO
Concentration
0.5 mg/ml
Format
Alexa Fluor® 488
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide