![AffiAB® Anti-Bov CD45R Alexa Fluor 488 [IVA103]](/web/image/product.product/83285/image_1024/%5BAFG-EXB-1786%5D%20AffiAB%C2%AE%20Anti-Bov%20CD45R%20Alexa%20Fluor%20488%20%5BIVA103%5D?unique=d31c23b)
Overview
CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.
Specificity:
The antibody IVA103 reacts with an extracellular epitope of CD45R antigen (bovine), a single chain type I transmembrane glycoprotein (member of the protein tyrosine phosphatase family), a restricted form of the CD45 family. CD45R is an essential regulator of T and B lymphocytes antigen receptor signaling and it is specifically expressed in hematopoietic cells.
Antigen
CD45R
Clone
IVA103
Species Reactivity
Cow
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Bovine leukocytes.
Application
FC (QC tested), ICC
Regulatory status
RUO
Concentration
0.5 mg/ml
Format
Alexa Fluor® 488
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide