![AffiAB® Anti-Hu CD44 Alexa Fluor 488 [MEM-85]](/web/image/product.product/83273/image_1024/%5BAFG-EXB-1774%5D%20AffiAB%C2%AE%20Anti-Hu%20CD44%20Alexa%20Fluor%20488%20%5BMEM-85%5D?unique=d31c23b)
Overview
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
Specificity:
The antibody MEM-85 reacts with an extracellular antigen of both cell surface-expressed and soluble form of CD44 antigen (Phagocyte glycoprotein 1), a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.) ; it is negative on platelets and hepatocytes.
Antigen
CD44
Clone
MEM-85
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2b
Immunogen
Leukocytes of a patient suffering from LGL Type Leukaemia.
Application
FC (QC tested), WB
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 488
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide