![AffiAB® Anti-Hu CD294 Alexa Fluor 488 [BM16]](/web/image/product.product/83262/image_1024/%5BAFG-EXB-1763%5D%20AffiAB%C2%AE%20Anti-Hu%20CD294%20Alexa%20Fluor%20488%20%5BBM16%5D?unique=d31c23b)
Overview
CD294 (prostaglandin D2 receptor 2) is a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells, but also on eosinophils and basophils. It mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of CD294 gene have been associated with asthma susceptibility. Outside the immune system CD294 is expressed e.g. in gut, heart, and brain. The intracellular C terminal tail contains sites for phosphorylation by protein kinase C.
Specificity:
The rat monoclonal antibody BM16 recognizes an extracellular epitope of CD294 / CRTH2 (prostaglandin D2 receptor 2), a G-protein-coupled seven-transmembrane protein expressed on Th2 cells, peripheral blood basophils and eosinophils.
Antigen
CD294
Clone
BM16
Species Reactivity
Human
Negative Species
N/A
Isotype
Rat IgG2a
Immunogen
Human CD294 transfected rat cell line TART/B19-12.10
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
Alexa Fluor® 488
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide