![AffiAB® Anti-Hu C5aR2 PE [1D9-M12]](/web/image/product.product/83222/image_1024/%5BAFG-EXB-1723%5D%20AffiAB%C2%AE%20Anti-Hu%20C5aR2%20PE%20%5B1D9-M12%5D?unique=0daa593)
Overview
C5aR2, also known as C5L2, is one of two receptors for C5a (anaphylatoxin) . It is coexpressed with C5aR1 (CD88) in neutrophils, as well as e.g. in mast cells, astrocytes, or macrophages, and seems to have both pro-inflammatory and anti-inflammatory roles, depending on circumstances. Unlike CD88, C5aR2 is not coupled to G-protein, thus the modulatory role is more likely.
Specificity:
The mouse monoclonal antibody 1D9-M12 recognizes an extracellular epitope on C5aR2 (C5L2), a C5a complement receptor, which is coexpressed with C5aR1 (CD88) in neutrophils, as well as e.g. in mast cells, astrocytes, or macrophages.
Antigen
C5aR2
Clone
1D9-M12
Species Reactivity
Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgG2a kappa
Immunogen
L1.2 cells transfected with human C5aR2
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide