![AffiAB® Anti-Hu CD272 PE [MIH26]](/web/image/product.product/83219/image_1024/%5BAFG-EXB-1720%5D%20AffiAB%C2%AE%20Anti-Hu%20CD272%20PE%20%5BMIH26%5D?unique=d31c23b)
Overview
CD272, a type I transmembrane glycoprotein, contains in its intracellular domain two ITIM sequences, which are upon CD272 triggering phosphorylated and recruit SHP phosphatases to attenuate cell activation. CD272 is expressed on B and T lymphocytes, NK cells, dendritic cells, and macrophages, and its ligand is CD270. Defects in CD272-CD270 inhibitory mechanism lead to autoimmune diseases. Overexpression of CD272 is a marker of tolerant T cells.
Specificity:
The mouse monoclonal antibody MIH26 recognizes an extracellular epitope of CD272, a transmembrane glycoprotein serving as a negative regulator of the activation in various leukocyte types.
Antigen
CD272
Clone
MIH26
Species Reactivity
Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgG2a kappa
Immunogen
cells transfected with human CD272
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide