![AffiAB® Anti-Hu CD51/CD61 PE [23C6]](/web/image/product.product/83199/image_1024/%5BAFG-EXB-1700%5D%20AffiAB%C2%AE%20Anti-Hu%20CD51-CD61%20PE%20%5B23C6%5D?unique=d31c23b)
Overview
CD51/CD61 (integrin alpha5beta3), also known as osteoclast functional antigen, serves as a vitronectin receptor, and binds also to fibronectin, fibrinogen, thrombospondin, osteopontin, collagen, and von Willebrand factor. Expression of this antigen increases with melanoma progression. In healthy individuals CD51/CD61 is expressed mainly on osteoclasts, placenta, and endothelial cells, at lower levels on platelets and macrophages.
Specificity:
The mouse monoclonal antibody 23C6 recognizes an extracellular epitope on CD51/CD61 complex, that is expressed mainly on human osteoclasts, but also e.g. on placenta, or melanoma cell lines. The epitope is native and sensitive to fixation. In chicken this antibody can be used to selectively identify the thrombocytes.
Antigen
CD51/CD61
Clone
23C6
Species Reactivity
Human, Chicken
Negative Species
Rabbit, Pig, Cow
Isotype
Mouse IgG1
Immunogen
A cell suspension containing osteoclasts from osteoclastomas
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide