![AffiAB® Anti-Hu CD328 PE [6-434]](/web/image/product.product/83175/image_1024/%5BAFG-EXB-1676%5D%20AffiAB%C2%AE%20Anti-Hu%20CD328%20PE%20%5B6-434%5D?unique=d31c23b)
Overview
CD328, also known as Siglec-7 or p75/AIRM1, is a 75 kDa type I transmembrane glycoprotein of sialic acid-binding immunoglobulin-like lectin (Siglec) family. CD328 binds to sialylated glycans with alpha2, 6 sialyl and alpha2, 8 disyalyl residues and mediates sialic acid-dependent cell-cell binding. As it contains in its intracellular part the immunoreceptor tyrosine-based inhibitory motif (ITIM), it serves as an inhibitory receptor, e.g. of NK cells.
Specificity:
The mouse monoclonal antibody 6-434 recognizes an extracellular epitope of CD328 (Siglec-7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes.
Antigen
CD328
Clone
6-434
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
human dendritic cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide