![AffiAB® Anti-Hu Myeloperoxidase PE [MPO421-8B2]](/web/image/product.product/83168/image_1024/%5BAFG-EXB-1669%5D%20AffiAB%C2%AE%20Anti-Hu%20Myeloperoxidase%20PE%20%5BMPO421-8B2%5D?unique=0daa593)
Overview
Myeloperoxidase (MPO) is a heme enzyme that is localized in azurophilic (primary) granules of myeloid cells and its synthesis occurs at an early stage of differentiation. The mature myeloperoxidase is a tetramer composed of two light (12 kDa) and two heavy (60 kDa) chains. This enzyme uses hydrogen peroxide to oxidize numerous substrates, including serotonin, melatonin or chloride, to produce reactive free radicals that contribute to immune reactions of myeloid cells against pathogens. Myeloperoxidase functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states such as atherosclerosis or acute pancreatitis.
Specificity:
The mouse monoclonal antibody MPO421-8B2 recognizes human myeloperoxidase, a heme protein present in intracellular granules of myeloblasts, neutrophils and monocytes. It is a marker of acute myelogenous leukemias and acute lymphoblastic leukemias.
Antigen
Myeloperoxidase
Clone
MPO421-8B2
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Human myeloperoxidase
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide