![AffiAB® Anti-Ms CD8b PE [H35-17.2]](/web/image/product.product/83157/image_1024/%5BAFG-EXB-1658%5D%20AffiAB%C2%AE%20Anti-Ms%20CD8b%20PE%20%5BH35-17.2%5D?unique=d31c23b)
Overview
The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Specificity:
The rat monoclonal antibody H35-17.2 recognizes an extracellular epitope of mouse CD8b, the 32-34 kDa beta chain of the CD8 coreceptor, expressed on cytotoxic T cells and thymocytes.
Antigen
CD8b
Clone
H35-17.2
Species Reactivity
Mouse
Negative Species
N/A
Isotype
Rat IgG2b kappa
Immunogen
Mouse CD8b
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.5 mg/ml
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide