![AffiAB® Anti-Helios PE [22F6]](/web/image/product.product/83149/image_1024/%5BAFG-EXB-1650%5D%20AffiAB%C2%AE%20Anti-Helios%20PE%20%5B22F6%5D?unique=0daa593)
Overview
Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros. Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development. Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Helios is expressed at early stages of thymocyte development. In mature T cells, Helios has been strongly associated with Treg cells.
Specificity:
The Armenian hamster monoclonal antibody 22F6 recognizes Helios, a transcription factor (intracellular antigen) expressed in some hematopoietic stem cells, and at high levels in thymic-derived regulatory T cells. The epitope is located between amino acids 51 and 107.
Antigen
Helios
Clone
22F6
Species Reactivity
Mouse, Human
Negative Species
N/A
Isotype
Armenian Hamster IgG
Immunogen
Peptide coresponding to the amino acids 51-107 of Helios
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide