![AffiAB® Anti-Ms CD49d PE [R1-2]](/web/image/product.product/83123/image_1024/%5BAFG-EXB-1624%5D%20AffiAB%C2%AE%20Anti-Ms%20CD49d%20PE%20%5BR1-2%5D?unique=d31c23b)
Overview
CD49d (integrin alpha 4), also known as very late antigen 4 alpha (VLA-4 alpha) is a cell surface glycoprotein constituting integrin complexes. CD49d heterodimerizes with CD29 (integrin beta 1) to form VLA-4 antigen, which is involved in cell-cell and cell-extracellular matrix interactions, which is a receptor for CD106 (VCAM) and fibronectin. CD79d also heterodimerizes with integrin beta 7 to form LPAM-1, which binds to MAdCAM-1 (mucosal vascular addressin) . These interactions are important for cell adhesion and activation.
Specificity:
The rat monoclonal antibody R1-2 recognizes an extracellular epitope of murine CD49d / Integrin alpha 4 (VLA-4 alpha), an approximately 150 kDa glycoprotein of the integrin family, expressed on multiple blood cell types.
Antigen
CD49d
Clone
R1-2
Species Reactivity
Mouse
Negative Species
N/A
Isotype
Rat IgG2b kappa
Immunogen
murine T lymphoma line TK1
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.5 mg/ml
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide