![AffiAB® Anti-Hu CD42a PE [GR-P]](/web/image/product.product/83122/image_1024/%5BAFG-EXB-1623%5D%20AffiAB%C2%AE%20Anti-Hu%20CD42a%20PE%20%5BGR-P%5D?unique=d31c23b)
Overview
CD42a, also known as glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
Specificity:
The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes an extracellular epitope of CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets.
Antigen
CD42a
Clone
GR-P
Species Reactivity
Dog, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Human acute lymphoblastic leukemia cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide