![AffiAB® Anti-DLL4 PE [MHD4-46]](/web/image/product.product/83113/image_1024/%5BAFG-EXB-1614%5D%20AffiAB%C2%AE%20Anti-DLL4%20PE%20%5BMHD4-46%5D?unique=0daa593)
Overview
DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
Specificity:
The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
Antigen
DLL4
Clone
MHD4-46
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
recombinant soluble human DLL4
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.1 mg/ml
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide