![AffiAB® Anti-Hu CD195 PE [T21/8]](/web/image/product.product/83108/image_1024/%5BAFG-EXB-1609%5D%20AffiAB%C2%AE%20Anti-Hu%20CD195%20PE%20%5BT21-8%5D?unique=d31c23b)
Overview
CD195 / CCR5 (also known as CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 alpha, MIP-1 beta, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 / CCR5 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120.
Specificity:
The mouse monoclonal antibody T21/8 recognizes an extracellular epitope on the N-teminus of CD195, an approximately 45 kDa G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells.
Antigen
CD195
Clone
T21/8
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
CCR5 peptide (Met1-Lys22) KLH conjugate
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide