![AffiAB® Anti-PCLO PE [PCLO-01]](/web/image/product.product/83100/image_1024/%5BAFG-EXB-1601%5D%20AffiAB%C2%AE%20Anti-PCLO%20PE%20%5BPCLO-01%5D?unique=0daa593)
Overview
PCLO (piccolo, also known as aczonin) is a large (more than 400 kDa) multidomain protein of the presynaptic cytomatrix in neurons, that is present in all vertebrate synapses, but is absent from invertebrates. It contains zinc finger and coiled-coil sequences, as well as N-terminal glutamine-rich sequence, and C-terminal PDZ domain followed by two C2 domains (C2A and C2B) . In vitro binding and transfection experiments suggested that PCLO binds to multiple proteins including profilin and L-type calcium channels. It is involved in neurotransmitter release and insulin secretion.
Specificity:
The mouse monoclonal antibody PCLO-01 recognizes PCLO (Piccolo), a more than 400 kDa multidomain protein expressed mainly in the presynaptic cytoplasmatic matrix of the neurons.
Antigen
PCLO
Clone
PCLO-01
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Human recombinant PCLO protein
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.1 mg/ml
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide