![AffiAB® Anti-Drebrin PE [DBN-N-03]](/web/image/product.product/83097/image_1024/%5BAFG-EXB-1598%5D%20AffiAB%C2%AE%20Anti-Drebrin%20PE%20%5BDBN-N-03%5D?unique=0daa593)
Overview
Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.
Specificity:
The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton.
Antigen
Drebrin
Clone
DBN-N-03
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2b
Immunogen
Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide