![AffiAB® Anti-Ms CD28 PE [37.51]](/web/image/product.product/83039/image_1024/%5BAFG-EXB-1540%5D%20AffiAB%C2%AE%20Anti-Ms%20CD28%20PE%20%5B37.51%5D?unique=d31c23b)
Overview
CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
Specificity:
The Syrian hamster monoclonal antibody 37.51 reacts with extracellular domain of mouse CD28 costimulatory receptor, a 45 kDa homodimeric protein expressed by thymocytes, mature T cells and NK cells.
Antigen
CD28
Clone
37.51
Species Reactivity
Mouse
Negative Species
N/A
Isotype
Golden Syrian Hamster IgG
Immunogen
Mouse T cell lymphoma EL-4 cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.5 mg/ml
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide