![AffiAB® Anti-Hu CD140b PE [18A2]](/web/image/product.product/83035/image_1024/%5BAFG-EXB-1536%5D%20AffiAB%C2%AE%20Anti-Hu%20CD140b%20PE%20%5B18A2%5D?unique=d31c23b)
Overview
CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.
Specificity:
The monoclonal antibody 18A2 recognizes an extracellular epitope of CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.
Antigen
CD140b
Clone
18A2
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
CD140b-transfected NIH 3T3 cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide